Biology:CPA5
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.[1][2]
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM][2]
References
- ↑ "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem 277 (17): 14954–64. Apr 2002. doi:10.1074/jbc.M112254200. PMID 11836249.
- ↑ 2.0 2.1 "Entrez Gene: CPA5 carboxypeptidase A5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93979.
External links
- Human CPA5 genome location and CPA5 gene details page in the UCSC Genome Browser.
Further reading
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H.
- "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome". J. Med. Genet. 40 (4): 249–56. 2003. doi:10.1136/jmg.40.4.249. PMID 12676894.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry 7 (3): 289–301. 2002. doi:10.1038/sj.mp.4001004. PMID 11920156.
- "A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium". Hum. Mol. Genet. 7 (3): 571–8. 1998. doi:10.1093/hmg/7.3.571. PMID 9546821.
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