Template:Amphetamine base in marketed amphetamine medications
From HandWiki
| drug | formula | molecular mass [note 1] |
amphetamine base [note 2] |
amphetamine base in equal doses |
doses with equal base content [note 3] | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| (g/mol) | (percent) | (30 mg dose) | ||||||||
| total | base | total | dextro- | levo- | dextro- | levo- | ||||
| dextroamphetamine sulfate[2][3] | (C9H13N)2•H2SO4 | |||||||||
| amphetamine sulfate[4] | (C9H13N)2•H2SO4 | |||||||||
| Adderall | ||||||||||
| 25% | dextroamphetamine sulfate[2][3] | (C9H13N)2•H2SO4 | ||||||||
| 25% | amphetamine sulfate[4] | (C9H13N)2•H2SO4 | ||||||||
| 25% | dextroamphetamine saccharate[5] | (C9H13N)2•C6H10O8 | ||||||||
| 25% | amphetamine aspartate monohydrate[6] | (C9H13N)•C4H7NO4•H2O | ||||||||
| lisdexamfetamine dimesylate[7] | C15H25N3O•(CH4O3S)2 | |||||||||
| amphetamine base suspension[note 4][8] | C9H13N | |||||||||
References
- ↑ "Molecular Weight Calculator". Lenntech. http://www.lenntech.com/calculators/molecular/molecular-weight-calculator.htm. Retrieved 19 August 2015.
- ↑ 2.0 2.1 "Dextroamphetamine Sulfate USP". Mallinckrodt Pharmaceuticals. March 2014. http://www2.mallinckrodt.com/WorkArea/DownloadAsset.aspx?id=2147491568. Retrieved 19 August 2015.
- ↑ 3.0 3.1 "D-amphetamine sulfate". Tocris. 2015. http://www.tocris.com/dispprod.php?ItemId=5305#.VXpspvlViko. Retrieved 19 August 2015.
- ↑ 4.0 4.1 "Amphetamine Sulfate USP". Mallinckrodt Pharmaceuticals. March 2014. http://www2.mallinckrodt.com/WorkArea/DownloadAsset.aspx?id=2147491599. Retrieved 19 August 2015.
- ↑ "Dextroamphetamine Saccharate". Mallinckrodt Pharmaceuticals. March 2014. http://www2.mallinckrodt.com/WorkArea/DownloadAsset.aspx?id=2147491576. Retrieved 19 August 2015.
- ↑ "Amphetamine Aspartate". Mallinckrodt Pharmaceuticals. March 2014. http://www2.mallinckrodt.com/WorkArea/DownloadAsset.aspx?id=2147491591. Retrieved 19 August 2015.
- ↑ "Vyvanse Prescribing Information". Shire US Inc.. May 2017. pp. 17–21. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021977s045,208510s001lbl.pdf. Retrieved 10 July 2017.
- ↑ For uniformity, molecular masses were calculated using the Lenntech Molecular Weight Calculator[1] and were within 0.01g/mol of published pharmaceutical values.
- ↑ Amphetamine base percentage = molecular massbase / molecular masstotal. Amphetamine base percentage for Adderall = sum of component percentages / 4.
- ↑ dose = (1 / amphetamine base percentage) × scaling factor = (molecular masstotal / molecular massbase) × scaling factor. The values in this column were scaled to a 30 mg dose of dextroamphetamine sulfate. Due to pharmacological differences between these medications (e.g., differences in the release, absorption, conversion, concentration, differing effects of enantiomers, half-life, etc.), the listed values should not be considered equipotent doses.
- ↑ This product (Dyanavel XR) is an oral suspension (i.e., a drug that is suspended in a liquid and taken by mouth) that contains 2.5 mg/mL of amphetamine base.[8] The amphetamine base contains dextro- to levo-amphetamine in a ratio of 3.2:1,[8] which is approximately the ratio in Adderall. The product uses an ion exchange resin to achieve extended release of the amphetamine base.[8]
