Chemistry:Y-27632
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| IUPAC name
(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
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| Properties | |
| C14H21N3O | |
| Molar mass | 247.342 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways.[1] Y-27632 selectively inhibits p160ROCK, although it does inhibit other protein kinases such as PKCs at higher concentrations.[2]
It has been studied for its effects on corneal endothelial cells (CECs) [3] and cardiac stem cells (CSCs).[4]
References
- ↑ Uehata, Masayoshi (1999). "Y-27632. Selective probe of ROCK/Rho-kinase". Jikken Igaku 17 (7): 850–855.
- ↑ Uehata, M; Ishizaki, T; Satoh, H; Ono, T; Kawahara, T; Morishita, T; Tamakawa, H; Yamagami, K et al. (1997). "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension". Nature 389 (6654): 990–4. doi:10.1038/40187. PMID 9353125. Bibcode: 1997Natur.389..990U.
- ↑ Peh, Gary S. L.; Adnan, Khadijah; George, Benjamin L.; Ang, Heng-Pei; Seah, Xin-Yi; Tan, Donald T.; Mehta, Jodhbir S. (2015-03-16). "The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach". Scientific Reports 5: 9167. doi:10.1038/srep09167. ISSN 2045-2322. PMID 25823914. Bibcode: 2015NatSR...5E9167P.
- ↑ Kan, Lijuan; Smith, Aubrie; Chen, Miao; Ledford, Benjamin T.; Fan, Huimin; Liu, Zhongmin; He, Jia-Qiang (2015-12-08). "Rho-Associated Kinase Inhibitor (Y-27632) Attenuates Doxorubicin-Induced Apoptosis of Human Cardiac Stem Cells". PLOS ONE 10 (12): e0144513. doi:10.1371/journal.pone.0144513. ISSN 1932-6203. PMID 26645568. Bibcode: 2015PLoSO..1044513K.
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