Chemistry:Tert-Butyl hypochlorite

From HandWiki
tert-Butyl hypochlorite
TBuOCl.svg
Names
Preferred IUPAC name
tert-Butyl hypochlorite
Identifiers
3D model (JSmol)
ChemSpider
EC Number
  • 208-072-7
UNII
UN number 3255
Properties
C4H9ClO
Molar mass 108.57 g·mol−1
Appearance Yellow liquid
Density 0.9583 g/cm3
Boiling point 79.6 °C (175.3 °F; 352.8 K) explosive
Sparingly
Hazards
GHS pictograms GHS02: FlammableGHS03: OxidizingGHS05: CorrosiveGHS08: Health hazard
GHS Signal word Danger
H225, H250, H251, H271, H314, H334
P210, P220, P221, P222, P233, P235+410, P240, P241, P242, P243, P260, P261, P264, P280, P283, P285, P301+330+331, P302+334, P303+361+353, P304+340, P304+341, P305+351+338, P306+360, P310, P321
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

tert-Butyl hypochlorite is the organic compound with the formula (CH3)3COCl. A yellow liquid, it is a rare example of an organic hypochlorite, i.e. a compound with an O-Cl bond. It is a reactive material that is useful for chlorinations. It can be viewed as a lipophilic version of sodium hypochlorite (bleach).[1]

Synthesis and reactions

It is produced by chlorination of tert-butyl alcohol in the presence of base:[2][3]

(CH
3
)
3
COH + Cl
2
+ NaOH → (CH
3
)
3
COCl + NaCl + H
2
O

tert-Butyl hypochlorite is useful in the preparation of organic chloramines:[4]

R2NH + t-BuOCl → R2NCl + t-BuOH

References

  1. Simpkins, Nigel S.; Cha, Jin K. (2006). "t-Butyl Hypochlorite". Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.rb388.pub2. ISBN 0471936235. 
  2. Teeter, H. M.; Bell, E. W. (1952). "tert-Butyl Hypochlorite". Org. Synth. 32: 20. doi:10.15227/orgsyn.032.0020. 
  3. Mintz, H. M.; Walling, C. (1969). "t-Butyl Hypochlorite". Org. Synth. 49: 9. doi:10.15227/orgsyn.049.0009. 
  4. Herranz, Eugenio; Sharpless, K. Barry (1983). "Osmium-catalyzed Vicinal Oxyamination of Olefins by N-chloro-N-Argentocarbamates: Ethyl Threo-[1-(2-hydroxy-1,2-diphenylethyl)]carbamate". Org. Synth. 61: 93. doi:10.15227/orgsyn.061.0093.