Chemistry:TC-S 7001
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C18H13ClF2N6O |
| Molar mass | 402.79 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
TC-S 7001 (Azaindole-1) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, with an IC50 of 0.6 nM at ROCK1 and 1.1 nM at ROCK2.[1] It has vasodilatory effects and has been used in research for a variety of applications.[2][3][4]
See also
References
- ↑ "Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase". British Journal of Pharmacology 152 (7): 1070–80. December 2007. doi:10.1038/sj.bjp.0707484. PMID 17934515.
- ↑ "Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension". The European Respiratory Journal 36 (4): 808–18. October 2010. doi:10.1183/09031936.00140309. PMID 20530035.
- ↑ "The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat". Canadian Journal of Physiology and Pharmacology 90 (7): 825–35. July 2012. doi:10.1139/y2012-061. PMID 22591047.
- ↑ "The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat". Urology 81 (2): 465.e7–14. February 2013. doi:10.1016/j.urology.2012.10.039. PMID 23374844.
 |  |
