Chemistry:Pethidine intermediate A
From HandWiki
Short description: Chemical compound
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| Routes of administration | N/A |
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| Formula | C13H16N2 |
| Molar mass | 200.285 g·mol−1 |
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Pethidine intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,[1] so pethidine intermediate A might also show opioid effects. It is scheduled by United Nations Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232. The 2014 annual manufacturing quota was 6 grammes (as an end product, presumably for research use).[2]
See also
- Moramide intermediate
- Methadone intermediate
- Pethidine intermediate B (norpethidine)
- Pethidine intermediate C (pethidinic acid)
References
- ↑ "Synthesis and biological evaluation of meperidine analogues at monoamine transporters". Journal of Medicinal Chemistry 48 (5): 1336–43. March 2005. doi:10.1021/jm0401614. PMID 15743177.
- ↑ "Conversion Factors for Controlled Substances". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice. http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html.
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