Chemistry:OPPPP
From HandWiki
Short description: Chemical compound
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| Formula | C23H27NO3 |
| Molar mass | 365.473 g·mol−1 |
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OPPPP (1-(3-Oxo-3-phenylpropyl)-4-phenyl-4-piperidinyl propionate) is an opioid drug related to medicines such as prodine. It is one of several compounds derived from MPPP, the reverse ester of pethidine, which were sold as designer drugs in the 1980s, but have been rarely encountered by law enforcement since the passage of the Federal Analogue Act in 1986.[1] In animal studies it was found to be around 1000× the potency of pethidine,[2] making it several times the potency of fentanyl and with similar hazards of respiratory depression and overdose. It is closely related to numerous compounds made by Janssen et al. for which the structure-activity relationship is well established.[3]
See also
References
- ↑ Designer Drugs Directory. Elsevier. 1998. pp. 147–148, 156. ISBN 0-444-20525-X.
- ↑ "Strong analgesics. Some 1-substituted 4-phenyl-4-propionoxypiperidines". Journal of Medicinal and Pharmaceutical Chemistry 91 (5): 913–9. September 1962. doi:10.1021/jm01240a003. PMID 14056434.
- ↑ "Compounds related to pethidine-IV. New general chemical methods of increasing the analgesic activity of pethidine". Journal of Medicinal and Pharmaceutical Chemistry 2: 31–45. February 1960. doi:10.1021/jm50008a003. PMID 14406754.
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