Chemistry:N1-Methyl-2-pyridone-5-carboxamide
From HandWiki
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| Names | |
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| Preferred IUPAC name
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide | |
| Other names
Nudifloramide; 6-Keto-1-methyl-nicotinamide
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3D model (JSmol)
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| Properties | |
| C7H8N2O2 | |
| Molar mass | 152.153 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
N1-Methyl-2-pyridone-5-carboxamide (also known as 1-methyl-6-oxopyridine-3-carboxamide or nudifloramide and abbreviated as 2PY, 2-Py or NMPC) is one of a number of metabolic products of nicotinamide adenine dinucleotide (NAD) degradation.[1][2][3][4] The presence of 2PY in human blood serum can be an indication of poor kidney performance or chronic kidney disease.[2][3] 2PY has been identified as a product of the metabolism of caffeine and niacin.[5]
2PY's molecular formula is C7H8N2O2 and its molecular weight 152.153 g/mol.[2]
References
- ↑ Shibata, Katsumi; Kawada, Teruo; Iwai, Kazuo (1988). "Simultaneous micro-determination of nicotinamide and its major metabolites, N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-3-carboxamide, by high-performance liquid chromatography". Journal of Chromatography B 424 (1): 23–28. doi:10.1016/S0378-4347(00)81072-5. PMID 2966806.
- ↑ 2.0 2.1 2.2 "1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide". US National Institutes of Health. https://pubchem.ncbi.nlm.nih.gov/compound/701-44-0#section=Top. Retrieved 20 February 2019.
- ↑ 3.0 3.1 Rutkowski, Boleslaw (2003). "N-methyl-2-pyridone-5-carboxamide: A novel uremic toxin?". Kidney International 63 (84): S19–S21. doi:10.1046/j.1523-1755.63.s84.36.x. PMID 12694300.
- ↑ Grison, Stephan (2016). "Metabolomics reveals dose effects of low-dose chronic exposure to uranium in rats: identification of candidate biomarkers in urine samples". Metabolomics 12 (10): 154. doi:10.1007/s11306-016-1092-8. PMID 27729830.
- ↑ Wong, Pierre; Bachki, Abderrazak; Banerjee, Kris; Leyland-Jones, Brian (2002). "Identification of N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-5-carboxamide as components in urine extracts of individuals consuming coffee". Journal of Pharmaceutical and Biomedical Analysis 30 (3): 773–780. doi:10.1016/S0731-7085(02)00384-9. PMID 12367703.
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