Chemistry:Lydicamycin
From HandWiki
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| IUPAC name
2-[21-[1-[(2,5-Dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)carbonyl]-1,2,4a,5,6,7,8,8a-octahydro-5,6-dihydroxy-1,3-dimethyl-2-naphthalenyl]-2,6,10,14,18-pentahydroxy-5,11,17,19-tetramethyl-4,8,12,16-heneicosatetraen-1-yl] 1-pyrrolidinecarboximidamide[1]
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C47H74N4O10 | |
| Molar mass | 855.127 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
Lydicamycin is an organic compound with the molecular formula C47H74N4O10.[2] Lydicamycin is an antibiotic with activity against Gram-positive bacteria.[3] The bacteria Streptomyces lydicamycinicus and Streptomyces platensis produces lydicamycin.[4][5]
References
- ↑ (in en) Lydicamycin (CAS 133352-27-9). https://www.caymanchem.com/product/20584.
- ↑ (in de) Lydicamycin | CAS 133352-27-9. https://www.scbt.com/de/p/lydicamycin-133352-27-9.
- ↑ Hayakawa, Yoichi; Kanamaru, Naoyuki; Shimazu, Akira; Seto, Haruo (1991). "Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity.". The Journal of Antibiotics 44 (3): 282–287. doi:10.7164/antibiotics.44.282. PMID 2026553.
- ↑ Furumai, Tamotsu; Eto, Keitaro; Sasaki, Tomomitsu; Higuchi, Hiroko; Onaka, Hiroyasu; Saito, Noriko; Fujita, Takeshi; Naoki, Hideo et al. (25 October 2002). "TPU-0037-A, B, C and D, Novel Lydicamycin Congeners with Anti-MRSA Activity from Streptomyces platensis TP-A0598" (in en). The Journal of Antibiotics 55 (10): 873–880. doi:10.7164/antibiotics.55.873. ISSN 0021-8820. PMID 12523820.
- ↑ Komaki, Hisayuki; Hosoyama, Akira; Igarashi, Yasuhiro; Tamura, Tomohiko (6 March 2020). "Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds". Microorganisms 8 (3): 370. doi:10.3390/microorganisms8030370. PMID 32155704.
Further reading
- Linskens, Hans-Ferdinand; Jackson, John F. (6 December 2012) (in en). Alkaloids. Springer Science & Business Media. p. 70. ISBN 978-3-642-84226-9.
- (in en) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 86. Springer Science & Business Media. 6 December 2012. p. 186. ISBN 978-3-7091-6029-9. https://books.google.com/books?id=6HztCAAAQBAJ&dq=Lydicamycin&pg=PA186.
- Morelli, Massimiliano; Bahar, Ofir; Papadopoulou, Kalliope K.; Hopkins, Donald L.; Obradović, Aleksa (29 October 2020) (in en). Role of Endophytes in Plant Health and Defense Against Pathogens. Frontiers Media SA. p. 75. ISBN 978-2-88966-098-8.
- Komaki, Hisayuki; Ichikawa, Natsuko; Hosoyama, Akira; Fujita, Nobuyuki; Igarashi, Yasuhiro (December 2015). "Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins". Standards in Genomic Sciences 10 (1): 58. doi:10.1186/s40793-015-0046-5. PMID 26380643.
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