Chemistry:Firibastat
From HandWiki
Short description: Chemical compound
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| Other names | QGC-001 |
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| Formula | C8H20N2O6S4 |
| Molar mass | 368.50 g·mol−1 |
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Firibastat is a prodrug of two brain aminopeptidase A inhibitors, developed to treat resistant hypertension.[1][2][3][4] It failed to show efficacy in a Phase III trial.[5]
References
- ↑ Ojha, Utkarsh; Ruddaraju, Sanjay; Sabapathy, Navukkarasu; Ravindran, Varun; Worapongsatitaya, Pitchaya; Haq, Jeesanul; Mohammed, Raihan; Patel, Vinod (2022). "Current and Emerging Classes of Pharmacological Agents for the Management of Hypertension". American Journal of Cardiovascular Drugs 22 (3): 271–285. doi:10.1007/s40256-021-00510-9. ISSN 1175-3277. PMID 34878631.
- ↑ Ferdinand, Keith C.; Balavoine, Fabrice; Besse, Bruno; Black, Henry R.; Desbrandes, Stephanie; Dittrich, Howard C.; Nesbitt, Shawna D. (9 July 2019). "Efficacy and Safety of Firibastat, A First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins: A Phase 2, Open-Label, Multicenter, Dose-Titrating Study" (in en). Circulation 140 (2): 138–146. doi:10.1161/CIRCULATIONAHA.119.040070. ISSN 0009-7322. PMID 31014072.
- ↑ Hansen, Emma; Grimm, Daniela; Wehland, Markus (27 January 2022). "Current Knowledge about the New Drug Firibastat in Arterial Hypertension". International Journal of Molecular Sciences 23 (3): 1459. doi:10.3390/ijms23031459. ISSN 1422-0067. PMID 35163378.
- ↑ Alomar, Sara Abdulrahman; Alghabban, Sarah Ali; Alharbi, Hadeel Abdulaziz; Almoqati, Mehad Fahad; Alduraibi, Yazid; Abu-Zaid, Ahmed (5 January 2021). "Firibastat, the first-in-class brain aminopeptidase a inhibitor, in the management of hypertension: A review of clinical trials". Avicenna Journal of Medicine 11 (1): 1–7. doi:10.4103/ajm.ajm_117_20. ISSN 2231-0770. PMID 33520782.
- ↑ "First-in-class aminopeptidase-A inhibitor fails to reduce treatment-resistant hypertension" (in en-us). 9 November 2022. https://sessions.hub.heart.org/aha-22/article/22539144/firstinclass-aminopeptidasea-inhibitor-fails-to-reduce-treatmentresistant-hypertension.
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