Chemistry:Crizotinib

From HandWiki
Short description: ALK inhibitor for treatment of non-small-cell lung cancer
Crizotinib
Crizotinib.svg
Clinical data
Trade namesXalkori, others
Other namesPF-02341066
1066
AHFS/Drugs.comMonograph
MedlinePlusa612018
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability43%
Protein binding91%
MetabolismLiver (CYP3A4/CYP3A5-mediated)
Elimination half-life42 hours
ExcretionFaeces (63%), urine (22%)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC21H22Cl2FN5O
Molar mass450.34 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Crizotinib, sold under the brand name Xalkori among others, is an anti-cancer medication used for the treatment of non-small cell lung carcinoma (NSCLC).[1][2][3][4] It acts as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor.[5][6][7]

Medical uses

Crizotinib is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) or relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive.[1][2]

It is also indicated for the treatment of unresectable, recurrent, or refractory inflammatory anaplastic lymphoma kinase (ALK)-positive myofibroblastic tumors (IMT).[1][8]

Mechanism of action

Human anaplastic lymphoma kinase in complex with crizotinib. PDB 2xp2[9]

Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases. About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion gene between EML4 ('echinoderm microtubule-associated protein-like 4') and ALK ('anaplastic lymphoma kinase'), which results in constitutive kinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype.[10] The kinase activity of the fusion protein is inhibited by crizotinib.[10] Patients with this gene fusion are typically younger non-smokers who do not have mutations in either the epidermal growth factor receptor gene (EGFR) or in the K-Ras gene.[10][11] The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide.[12][13]

ALK mutations are thought to be important in driving the malignant phenotype in about 15% of cases of neuroblastoma, a rare form of peripheral nervous system cancer that occurs almost exclusively in very young children.[14]

Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms.[15]

Crizotinib is thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells.[15][16] Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.[17]

Society and culture

Legal status

On August 24, 2011, the U.S. Food and Drug Administration approved crizotinib to treat certain late-stage (locally advanced or metastatic) non-small cell lung cancers that express the abnormal anaplastic lymphoma kinase (ALK) gene.[3] Approval required a companion molecular test for the EML4-ALK fusion. In March 2016, the U.S. Food and Drug Administration approved crizotinib in ROS1-positive non-small cell lung cancer.[18]

In October 2012, the European Medicines Agency (EMA) approved the use of crizotinib to treat non-small cell lung cancers that express the abnormal anaplastic lymphoma kinase (ALK) gene.[2][19]

Research

Lung cancer

Crizotinib caused tumors to shrink or stabilize in 90% of 82 patients carrying the ALK fusion gene.[11][12] Tumors shrank at least 30% in 57% of people treated.[12] [20] Most had adenocarcinoma, and had never smoked or were former smokers.[11] They had undergone treatment with an average of three other drugs prior to receiving crizotinib, and only 10% were expected to respond to standard therapy.[11][21] They were given 250 mg crizotinib twice daily for a median duration of six months.[11] Approximately 50% of these patients had at least one side effect, such as nausea, vomiting, or diarrhea.[21] Some responses to crizotinib have lasted up to 15 months.[21]

A Phase III trial, PROFILE 1007,[22] compares crizotinib to standard second line chemotherapy (pemetrexed or taxotere) in the treatment of ALK-positive NSCLC.[23][13][24] Additionally, a phase 2 trial, PROFILE 1005, studies patients meeting similar criteria who have received more than one line of prior chemotherapy.[13]

In February 2016, the J-ALEX phase III study comparing alectinib with crizotinib ALK-positive metastatic NSCLC was terminated early because an interim analysis showed that progression-free survival was longer with alectinib.[25] These results were confirmed in a 2017 analysis.[26]

Lymphomas

In people affected by relapsed or refractory ALK+ anaplastic large cell lymphoma, crizotinib produced objective response rates ranging from 65% to 90% and 3 year progression free survival rates of 60-75%. No relapse of the lymphoma was ever observed after the initial 100 days of treatment. Treatment must be continued indefinitely at present.[27][28][29]

Other cancers

Crizotinib is also being tested in clinical trials of advanced disseminated neuroblastoma.[30]

References

  1. ↑ 1.0 1.1 1.2 1.3 "Xalkori- crizotinib capsule". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2a51b0de-47d6-455e-a94c-d2c737b04ff7. 
  2. ↑ 2.0 2.1 2.2 2.3 "Xalkori EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/xalkori. 
  3. ↑ 3.0 3.1 "Drug Approval Package: Xalkori Capsules (crizotinib) NDA #202570". 27 September 2011. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000TOC.cfm. 
  4. ↑ "Summary Review for Regulatory Action". August 26, 2011. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000SumR.pdf. 
  5. ↑ "Crizotinib in the treatment of non-small-cell lung cancer". Expert Opinion on Pharmacotherapy 13 (8): 1195–201. June 2012. doi:10.1517/14656566.2012.688029. PMID 22594847. 
  6. ↑ "Clinical use of crizotinib for the treatment of non-small cell lung cancer". Biologics: Targets and Therapy 7: 91–101. 2013. doi:10.2147/BTT.S29026. PMID 23671386. 
  7. ↑ "Crizotinib: A comprehensive review". South Asian Journal of Cancer 2 (2): 91–7. April 2013. doi:10.4103/2278-330X.110506. PMID 24455567. 
  8. ↑ "FDA approves crizotinib for ALK-positive inflammatory myofibroblastic tumor". U.S. Food and Drug Administration (FDA) (Press release). 14 July 2022. Archived from the original on 14 July 2022. Retrieved 14 July 2022. This article incorporates text from this source, which is in the public domain.
  9. ↑ "Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)". Journal of Medicinal Chemistry 54 (18): 6342–63. September 2011. doi:10.1021/jm2007613. PMID 21812414. 
  10. ↑ 10.0 10.1 10.2 "Maintenance Therapy for Non-Small Cell Lung Cancer". MedscapeCME. 2010-05-12. http://cme.medscape.com/viewarticle/720896_transcript. 
  11. ↑ 11.0 11.1 11.2 11.3 11.4 "ALK inhibitor crizotinib has high response rate in patients with ALK-positive NSCLC". HemOncToday. 2010-06-05. http://www.hemonctoday.com/article.aspx?rid=65251. 
  12. ↑ 12.0 12.1 12.2 "Advances Come in War on Cancer". The Wall Street Journal. 2010-06-07. https://www.wsj.com/articles/SB10001424052748704002104575291103764336126?mod=WSJ_WSJ_US_News_3. 
  13. ↑ 13.0 13.1 13.2 "Pfizer Oncology To Present New Clinical Data From Ten Molecules Across Multiple Tumor Types" (PDF) (Press release). Pfizer Oncology. 2010-05-20. Archived from the original (PDF) on 2010-06-12. Retrieved 2010-06-07.
  14. ↑ "Molecular pathogenesis of peripheral neuroblastic tumors". Oncogene 29 (11): 1566–79. March 2010. doi:10.1038/onc.2009.518. PMID 20101209. 
  15. ↑ 15.0 15.1 Clinical trial number NCT00585195 for "A Study Of Oral PF-02341066, A c-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer" at ClinicalTrials.gov
  16. ↑ "Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma". Molecular Cancer Therapeutics 6 (12 Pt 1): 3314–22. December 2007. doi:10.1158/1535-7163.MCT-07-0365. PMID 18089725. 
  17. ↑ "An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms". Cancer Research 67 (9): 4408–17. May 2007. doi:10.1158/0008-5472.CAN-06-4443. PMID 17483355. 
  18. ↑ "NICE backs Pfizer's Xalkori after squeezing out a new discount - FiercePharma". 18 August 2016. http://www.fiercepharma.com/pharma/nice-backs-pfizer-s-xalkori-after-squeezing-out-a-new-discount. 
  19. ↑ "Xalkori - EMEA/H/C/002489 - T/0059". European Medicines Agency. 2012. https://www.ema.europa.eu/documents/product-information/xalkori-epar-product-information_en.pdf. 
  20. ↑ Helwick (2010). "Novel Agent Demonstrates Striking Activity in ALK-positive NSCLC". http://www.ascopost.com/articles/july-2010/novel-agent-demonstrates-striking-activity-in-alk-positive-nsclc.  NB Fig 1.
  21. ↑ 21.0 21.1 21.2 "Gene-based lung cancer drug shows promise". NBC News. 2010-05-07. http://www.nbcnews.com/id/37527542. 
  22. ↑ "Crizotinib Clinical Trials – Currently Ongoing and/or Enrolling". Fact Sheet. Pfizer. http://www.pfizer.com/files/news/asco/crizotinib_fact_sheet.pdf. 
  23. ↑ Clinical trial number NCT00932451 for "An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene" at ClinicalTrials.gov
  24. ↑ Clinical trial number NCT00932893 for "An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene" at ClinicalTrials.gov
  25. ↑ "Chugai's ALK Inhibitor "Alecensa" Trial Stopped Early for Benefit". Roche. February 2016. http://www.roche.com/inv-update-2016-02-10b-annex.pdf. 
  26. ↑ "FDA approves Alecensa for ALK-positive metastatic non-small cell lung cancer". Healio. November 2017. https://www.healio.com/hematology-oncology/lung-cancer/news/online/%7Ba97a3d66-e12d-42a5-9b72-4d330b151aaf%7D/fda-approves-alecensa-for-alk--positive-metastatic-non-small-cell-lung-cancer. 
  27. ↑ "Clinical Activity of Crizotinib In Advanced, Chemoresistant ALK+ Lymphoma Patients". Annual Meeting of the American Society of Hematology (Orlando, Florida). 2010. 
  28. ↑ "Crizotinib in anaplastic large-cell lymphoma". The New England Journal of Medicine 364 (8): 775–6. February 2011. doi:10.1056/NEJMc1013224. PMID 21345110. 
  29. ↑ "Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients". Journal of the National Cancer Institute 106 (2): djt378. February 2014. doi:10.1093/jnci/djt378. PMID 24491302. 
  30. ↑ "Inhibition of ALK mutated neuroblastomas by the selective inhibitor PF-02341066". J Clin Oncol 27 (15s. suppl; abstr 10008b): 10008b. 2009. doi:10.1200/jco.2009.27.15_suppl.10008b. http://meeting.ascopubs.org/cgi/content/short/27/15S/10008b. 

External links



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Crizotinib&oldid=3335532"