Chemistry:Apoptozole
From HandWiki
Short description: Drug
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| Trade names | Apoptozole |
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| Formula | C33H25F6N3O3 |
| Molar mass | 625.6 g·mol−1 |
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Apoptozole is a drug that acts as a potent and selective inhibitor of the heat shock protein Hsp70, and was one of the first compounds developed to act at this target. It induces apoptosis in susceptible cells, and displays anti-cancer, anti-malarial and antiviral activity. The promising results in animal studies makes it likely that either apoptozole or compounds with similar modes of action will be further researched as potential therapeutics in the future.[1][2][3][4][5]
References
- ↑ "A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities". Chemistry & Biology 22 (3): 391–403. March 2015. doi:10.1016/j.chembiol.2015.02.004. PMID 25772468.
- ↑ "Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules". Scientific Reports 7 (1): 3537. June 2017. doi:10.1038/s41598-017-03814-6. PMID 28615625. Bibcode: 2017NatSR...7.3537P.
- ↑ "Repurposing drugs to target the malaria parasite unfolding protein response". Scientific Reports 8 (1): 10333. July 2018. doi:10.1038/s41598-018-28608-2. PMID 29985421. Bibcode: 2018NatSR...810333C.
- ↑ "Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms". Cell Chemical Biology 25 (10): 1242–1254.e8. October 2018. doi:10.1016/j.chembiol.2018.06.010. PMID 30057298.
- ↑ "Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections". ACS Infectious Diseases 6 (5): 832–843. February 2020. doi:10.1021/acsinfecdis.9b00376. PMID 31967789.
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