Chemistry:3,5-Difluoro-4-hydroxybenzylidene imidazolidinone

From HandWiki
DFHBI[1]
DFHBI.png
Names
IUPAC name
(5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2,3-dimethyl-4H-imidazol-4-one[1]
Other names
  • 3,5-Difluoro-4-hydroxybenzylidene imidazolidinone
  • 3,5-Difluoro-4-hydroxybenzylidene imidazolinone
  • (Z)-4-(3,5-Difluoro-4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one[2]
Identifiers
3D model (JSmol)
ChemSpider
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

3,5-Difluoro-4-hydroxybenzylidene imidazolidinone or DFHBI is an imidazolidinone fluorophore used in various biochemical studies. The benzene ring of DFHBI can freely rotate around the single bond but when it is fixed in planar conformation, DFHBI floresces.[2] It is a synthetic analog of the GFP fluorophore.

References

  1. ↑ 1.0 1.1 "DFHBI 1241390-29-3". https://www.sigmaaldrich.com/CZ/en/product/sigma/sml1627. 
  2. ↑ 2.0 2.1 Dou, Jiayi; Vorobieva, Anastassia A.; Sheffler, William; Doyle, Lindsey A.; Park, Hahnbeom; Bick, Matthew J.; Mao, Binchen; Foight, Glenna W. et al. (September 2018). "De novo design of a fluorescence-activating β-barrel" (in en). Nature 561 (7724): 485–491. doi:10.1038/s41586-018-0509-0. ISSN 0028-0836. PMID 30209393. 




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