Chemistry:1-Hydroxy-7-azabenzotriazole
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| Preferred IUPAC name
3H-[1,2,3]Triazolo[4,5-b]pyridin-3-ol | |
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3D model (JSmol)
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| Properties | |
| C5H4N4O | |
| Molar mass | 136.114 g·mol−1 |
| Density | 0.973 g/mL |
| Melting point | 213-216°C |
| Hazards | |
| GHS pictograms |    
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| GHS Signal word | danger |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
1-Hydroxy-7-azabenzotriazole (HOAt) is a triazole used as a peptide coupling reagent.[2] It suppresses racemization that can otherwise occur during the reaction.[3]
HOAt has a melting point between 213 and 216 degrees Celsius.[4] As a liquid, it is transparent and without any color.
References
- ↑ GHS: Sigma Aldrich 445452
- ↑ Carpino, Louis A (1993). "1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive". Journal of the American Chemical Society 115 (10): 4397–4398. doi:10.1021/ja00063a082.
- ↑ Valeur, Eric; Bradley, Mark (2009). "Amide bond formation: beyond the myth of coupling reagents". Chemical Society Reviews 38 (2): 606–631. doi:10.1039/b701677h. PMID 19169468.
- ↑ "HOAt". https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3256884.htm.
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