Biology:UDP-glucuronic acid dehydrogenase
From HandWiki
Short description: Class of enzymes
| UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.305 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) (EC 1.1.1.305, UDP-GlcUA decarboxylase, ArnADH) is an enzyme with systematic name UDP-glucuronate:NAD+ oxidoreductase (decarboxylating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- UDP-glucuronate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+
The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).
References
- ↑ "A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose". The Journal of Biological Chemistry 280 (14): 14154–67. April 2005. doi:10.1074/jbc.M414265200. PMID 15695810.
- ↑ "Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance". Biochemistry 43 (42): 13370–9. October 2004. doi:10.1021/bi048551f. PMID 15491143.
- ↑ "Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis". The Journal of Biological Chemistry 280 (24): 23000–8. June 2005. doi:10.1074/jbc.M501534200. PMID 15809294.
- ↑ "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance". Structure 13 (6): 929–42. June 2005. doi:10.1016/j.str.2005.03.018. PMID 15939024.
- ↑ "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". The Journal of Biological Chemistry 282 (49): 36077–89. December 2007. doi:10.1074/jbc.M706172200. PMID 17928292.
External links
- UDP-glucuronic+acid+dehydrogenase+(UDP-4-keto-hexauronic+acid+decarboxylating) at the US National Library of Medicine Medical Subject Headings (MeSH)
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