Biology:Trichodiene synthase

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trichodiene synthase
Identifiers
EC number4.2.3.6
CAS number101915-76-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme trichodiene synthase (EC 4.2.3.6) catalyzes the chemical reaction

(2E,6E)-farnesyl diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] trichodiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1YJ4, 1YYQ, 1YYR, 1YYS, 1YYT, 1YYU, 2AEK, 2AEL, and 2AET.

References