Biology:TRNA-dihydrouridine20 synthase (NAD(P)+)

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Short description: Class of enzymes
TRNA-dihydrouridine20 synthase (NAD(P)+)
Identifiers
EC number1.3.1.91
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

TRNA-dihydrouridine20 synthase (NAD(P)+) (EC 1.3.1.91, Dus2p, tRNA-dihydrouridine synthase 2) is an enzyme with systematic name tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

5,6-dihydrouracil20 in tRNA + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] uracil20 in tRNA + NAD(P)H + H+

This enzyme specifically modifies uracil20 in tRNA.

References

  1. "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry 279 (17): 17850–60. April 2004. doi:10.1074/jbc.M401221200. PMID 14970222. 
  2. "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA 8 (3): 370–81. March 2002. doi:10.1017/S1355838202029825. PMID 12003496. 
  3. "Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction". The Journal of Biological Chemistry 284 (16): 10324–33. April 2009. doi:10.1074/jbc.M806137200. PMID 19139092. 
  4. "A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis". Cancer Research 65 (13): 5638–46. July 2005. doi:10.1158/0008-5472.CAN-05-0600. PMID 15994936. 

External links