Biology:Sterigmatocystin 8-O-methyltransferase
| sterigmatocystin 7-O-methyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.1.1.110 | ||||||||
| CAS number | 116958-29-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a sterigmatocystin 8-O-methyltransferase (EC 2.1.1.110) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + sterigmatocystin [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
Thus, the two substrates of this enzyme are S-adenosyl methionine and sterigmatocystin, whereas its two products are S-adenosylhomocysteine and 8-O-methylsterigmatocystin.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase. Other names in common use include sterigmatocystin methyltransferase, O-methyltransferase II, sterigmatocystin 7-O-methyltransferase (incorrect), S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase, and (incorrect).
References
- "Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus". Appl. Environ. Microbiol. 53 (5): 1028–33. 1987. PMID 3111363.
- "Two distinct O-methyltransferases in aflatoxin biosynthesis". Appl. Environ. Microbiol. 55 (9): 2172–7. 1989. PMID 2802602.
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