Biology:SroB RNA

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sroB RNA
RF00368.jpg
Predicted secondary structure and sequence conservation of sroB
Identifiers
SymbolsroB
RfamRF00368
Other data
RNA typeGene; sRNA
Domain(s)Bacteria
SO0000655
PDB structuresPDBe

The sroB RNA (also known as MicM, rybC, or ChiX) is a non-coding RNA gene of 90 nucleotides in length. sroB is found in several Enterobacterial species but its function is unknown.[1][2] SroB is found in the intergenic region on the opposite strand to the ybaK and ybaP genes.[1] SroB is expressed in stationary phase.[1] Experiments have shown that SroB is a Hfq binding sRNA.[2][3]

Further evidence has shown that SroB negatively regulates the outer membrane protein YbfM by sequestering the ribosome binding site of ybfM mRNA by an antisense interaction.[4] SroB also regulates the DpiA/DpiB two-component system.[5] Furthermore, SroB itself appears to be the target of a non-coding transcript from the chbBC intergenic region.[6][7][8]

References

  1. ↑ 1.0 1.1 1.2 "RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria". Nucleic Acids Res. 31 (22): 6435–6443. 2003. doi:10.1093/nar/gkg867. PMID 14602901. 
  2. ↑ 2.0 2.1 "Global analysis of small RNA and mRNA targets of Hfq". Mol. Microbiol. 50 (4): 1111–1124. November 2003. doi:10.1046/j.1365-2958.2003.03734.x. PMID 14622403. 
  3. ↑ Burkholder, William F., ed (2008). "Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq". PLOS Genet. 4 (8): e1000163. doi:10.1371/journal.pgen.1000163. PMID 18725932. 
  4. ↑ "A conserved small RNA promotes silencing of the outer membrane protein YbfM". Mol. Microbiol. 72 (3): 566–577. April 2009. doi:10.1111/j.1365-2958.2009.06688.x. PMID 19400782. 
  5. ↑ Mandin, P.; Gottesman, S. (2009). "A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system". Molecular Microbiology 72 (3): 551–565. doi:10.1111/j.1365-2958.2009.06665.x. PMID 19426207. 
  6. ↑ "Switching off small RNA regulation with trap-mRNA.". Mol Microbiol 73 (5): 790–800. 2009. doi:10.1111/j.1365-2958.2009.06807.x. PMID 19682266. 
  7. ↑ Vogel J (July 2009). "An RNA trap helps bacteria get the most out of chitosugars". Mol. Microbiol. 73 (5): 737–741. doi:10.1111/j.1365-2958.2009.06806.x. PMID 19659640. http://www3.interscience.wiley.com/resolve/doi/abs?DOI=10.1111/j.1365-2958.2009.06806.x. 
  8. ↑ "Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target.". Genes Dev 23 (17): 2004–2015. 2009. doi:10.1101/gad.541609. PMID 19638370. 

Further reading

  • "Interplay of transcriptional and small RNA-dependent control mechanisms regulates chitosugar uptake in Escherichia coli and Salmonella.". Molecular Microbiology 92 (4): 648–658. March 5, 2014. doi:10.1111/mmi.12573. PMID 24593230. 

External links



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