Biology:Spleen exonuclease
From HandWiki
Short description: Enzyme
| Spleen exonuclease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.16.1 | ||||||||
| CAS number | 9068-54-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Spleen exonuclease (EC 3.1.16.1, 3'-exonuclease, spleen phosphodiesterase, 3'-nucleotide phosphodiesterase, phosphodiesterase II) is an enzyme.[1] This enzyme catalyses the following chemical reaction
Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates (exonuclease type b)
This enzyme has a preference for single-stranded substrate.
PLD3 and/or PLD4 might be the genes encoding spleen exonuclease, as they have similar substrate specificity and tissue distribution.[2]
References
- ↑ "Spleen acid nuclease". The Enzymes. 4 (3rd ed.). New York: Academic Press. 1971. pp. 329–336.
- ↑ "PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing". Nature Immunology 19 (9): 942–953. September 2018. doi:10.1038/s41590-018-0179-y. PMID 30111894.
External links
- Spleen+exonuclease at the US National Library of Medicine Medical Subject Headings (MeSH)
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