Biology:Salutaridinol 7-O-acetyltransferase

From HandWiki
salutaridinol 7-O-acetyltransferase
Identifiers
EC number2.3.1.150
CAS number156859-13-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a salutaridinol 7-O-acetyltransferase (EC 2.3.1.150) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + salutaridinol [math]\displaystyle{ \rightleftharpoons }[/math] CoA + 7-O-acetylsalutaridinol

Thus, the two substrates of this enzyme are acetyl-CoA and salutaridinol, whereas its two products are CoA and 7-O-acetylsalutaridinol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:salutaridinol 7-O-acetyltransferase. This enzyme participates in alkaloid biosynthesis i.

References

  • "Closure of the oxide bridge in morphine biosynthesis". Tetrahedron Lett. 35 (23): 3897–3900. 1994. doi:10.1016/S0040-4039(00)76696-2. 
  • "Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis". J. Biol. Chem. 270 (52): 31091–6. 1995. doi:10.1074/jbc.270.52.31091. PMID 8537369.