Biology:S100A14
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.[1]
Function
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.[2][3]
References
- ↑ "Entrez Gene: S100 calcium binding protein A14". https://www.ncbi.nlm.nih.gov/gene/57402.
- ↑ "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports 23 (1): 45–52. Jan 2010. doi:10.3892/or_00000604. PMID 19956863.
- ↑ "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research 69 (8): 3451–7. Apr 2009. doi:10.1158/0008-5472.CAN-08-4231. PMID 19351828.
Further reading
- "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. Feb 1995. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
- "Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15". Journal of Immunology 181 (2): 1499–1506. Jul 2008. doi:10.4049/jimmunol.181.2.1499. PMID 18606705.
- "Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients". International Journal of Immunogenetics 36 (4): 217–22. Aug 2009. doi:10.1111/j.1744-313X.2009.00858.x. PMID 19601998.
- "S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)". PLOS ONE 6 (4): e19375. 2011. doi:10.1371/journal.pone.0019375. PMID 21559403. Bibcode: 2011PLoSO...619375J.
- "S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4". The Journal of Investigative Dermatology 127 (11): 2596–604. Nov 2007. doi:10.1038/sj.jid.5700946. PMID 17625598.
- "S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest". Oral Oncology 48 (3): 219–25. Mar 2012. doi:10.1016/j.oraloncology.2011.10.001. PMID 22032898.
- "Purification, crystallization and preliminary X-ray diffraction of human S100A15". Acta Crystallographica Section F 62 (Pt 5): 467–470. May 2006. doi:10.1107/S1744309106012838. PMID 16682778.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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