Biology:RsmY RNA family
From HandWiki
| RsmY RNA family | |
|---|---|
 Predicted secondary structure and sequence conservation of RsmY | |
| Identifiers | |
| Symbol | RsmY |
| Rfam | RF00195 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | 0000655 |
| PDB structures | PDBe |
The rsmY RNA family is a set of related non-coding RNA genes, that like RsmZ, is regulated by the GacS/GacA signal transduction system in the plant-beneficial soil bacterium and biocontrol model organism Pseudomonas fluorescens CHA0. GacA/GacS target genes are translationally repressed by the small RNA binding protein RsmA. RsmY and RsmZ RNAs bind RsmA to relieve this repression and so enhance secondary metabolism and biocontrol traits.[1]
Studies in Legionella pneumophila have shown that the ncRNAs RsmY and RsmZ together with the proteins LetA and CsrA are involved in a regulatory cascade. Also, it appears that these ncRNAs are regulated by RpoS sigma-factor.[2]
See also
- CsrB/RsmB RNA family
- CsrC RNA family
- PrrB/RsmZ RNA family
- RsmX
- RsmW sRNA
- CsrA protein
References
- ↑ "RsmY, a small regulatory RNA, is required in concert with RsmZ for GacA-dependent expression of biocontrol traits in Pseudomonas fluorescens CHA0". Molecular Microbiology 50 (4): 1361–1379. November 2003. doi:10.1046/j.1365-2958.2003.03774.x. PMID 14622422.
- ↑ "The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors". Molecular Microbiology 72 (4): 995–1010. May 2009. doi:10.1111/j.1365-2958.2009.06705.x. PMID 19400807.
Further reading
- "The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs". Molecular Microbiology 73 (3): 434–445. August 2009. doi:10.1111/j.1365-2958.2009.06782.x. PMID 19602144.
- "Distinct and overlapping binding sites of Pseudomonas aeruginosa Hfq and RsmA proteins on the non-coding RNA RsmY". Biochemical and Biophysical Research Communications 352 (3): 769–773. January 2007. doi:10.1016/j.bbrc.2006.11.084. PMID 17141182.
- "A repeated GGA motif is critical for the activity and stability of the riboregulator RsmY of Pseudomonas fluorescens". The Journal of Biological Chemistry 279 (24): 25066–25074. June 2004. doi:10.1074/jbc.M401870200. PMID 15031281.
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