Biology:RMI1
 Generic protein structure example |
RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene.[1][2]
Meiosis
During meiosis in budding yeast Saccharomyces cerevisiae, TOP3 (a type I topoisomerase) and its accessory factor RMI1 form a heterodimer that functions to allow passage of one DNA single strand through another. The TOP3-RMI1 heterodimer associates with Sgs1 (Bloom helicase ortholog) to form a complex that catalyzes dissolution of double Holliday junctions.[3] Furthermore, the TOP3-RMI1 heterodimer participates in all meiotic recombination functions associated with Sgs1, most significantly as an early recombination intermediate chaperone, promoting regulated crossover and non-crossover recombination and preventing accumulation of aberrant recombination intermediates.[4] In particular, the TOP3-RMI1–SGS1 complex promotes early formation of non-crossover recombinants during meiosis.[4]
References
- ↑ "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity". EMBO J 24 (7): 1465–76. May 2005. doi:10.1038/sj.emboj.7600622. PMID 15775963.
- ↑ "Entrez Gene: RMI1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80010.
- ↑ "The dissolution of double Holliday junctions". Cold Spring Harb Perspect Biol 6 (7): a016477. 2014. doi:10.1101/cshperspect.a016477. PMID 24984776.
- ↑ 4.0 4.1 "Top3-Rmi1 DNA single-strand decatenase is integral to the formation and resolution of meiotic recombination intermediates". Mol. Cell 57 (4): 583–94. 2015. doi:10.1016/j.molcel.2015.01.020. PMID 25699707.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. 35 (2): 165–70. 2003. doi:10.1038/ng1241. PMID 12973351.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates". Proc. Natl. Acad. Sci. U.S.A. 103 (11): 4068–73. 2006. doi:10.1073/pnas.0508295103. PMID 16537486. Bibcode: 2006PNAS..103.4068W.
- "A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75". J. Biol. Chem. 281 (20): 13861–4. 2006. doi:10.1074/jbc.C600051200. PMID 16595695.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex". J. Biol. Chem. 282 (43): 31484–92. 2007. doi:10.1074/jbc.M706116200. PMID 17728255.
- "Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma". Cancer Lett. 258 (1): 38–44. 2008. doi:10.1016/j.canlet.2007.08.005. PMID 17900800.
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