Biology:Pyridine N-methyltransferase

From HandWiki
pyridine N-methyltransferase
Identifiers
EC number2.1.1.87
CAS number104327-10-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a pyridine N-methyltransferase (EC 2.1.1.87) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + pyridine [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N-methylpyridinium

Thus, the two substrates of this enzyme are S-adenosyl methionine and pyridine, whereas its two products are S-adenosylhomocysteine and N-methylpyridinium.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:pyridine N-methyltransferase. This enzyme is also called pyridine methyltransferase.

References

  • "N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction". Xenobiotica 16 (7): 645–50. 1986. doi:10.3109/00498258609043554. PMID 3751119.