Biology:Polyprenol reductase
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Short description: Class of enzymes
| Polyprenol reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.94 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Polyprenol reductase (EC 1.3.1.94, SRD5A3 (gene), DFG10 (gene)) is an enzyme with systematic name ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- ditrans, polycis-dolichol + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] ditrans, polycis-polyprenol + NADPH + H+
The reaction occurs in the reverse direction.
See also
- SRD5A3
- DFG10
References
- ↑ "Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver". The Journal of Biological Chemistry 268 (14): 10109–13. May 1993. PMID 8486680.
- ↑ "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell 142 (2): 203–17. July 2010. doi:10.1016/j.cell.2010.06.001. PMID 20637498.
External links
- Polyprenol+reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
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