Biology:Pestivirus NS3 polyprotein peptidase

From HandWiki
Pestivirus NS3 polyprotein peptidase
Identifiers
EC number3.4.21.113
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Pestivirus NS3 polyprotein peptidase (EC 3.4.21.113, border disease virus NS3 endopeptidase, BDV NS3 endopeptidase, bovine viral diarrhea virus NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3 endopeptidase, p80) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites

The genomes of Cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80).

References

  1. "Pestivirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing". Virology 184 (1): 341–50. September 1991. doi:10.1016/0042-6822(91)90850-b. PMID 1651596. 
  2. "Serine protease of pestiviruses: determination of cleavage sites". Journal of Virology 71 (7): 5415–22. July 1997. PMID 9188613. 
  3. "Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication". Journal of Virology 71 (7): 5312–22. July 1997. PMID 9188600. 
  4. "NS3 serine protease of bovine viral diarrhea virus: characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions". Virology 273 (2): 351–63. August 2000. doi:10.1006/viro.2000.0425. PMID 10915606. 

External links