Biology:Peptide-methionine (S)-S-oxide reductase
From HandWiki
| Peptide-methionine (S)-S-oxide reductase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.8.4.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Peptide-methionine (S)-S-oxide reductase (EC 1.8.4.11, MsrA, methionine sulphoxide reductase A, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase A, peptide methionine sulfoxide reductase, formerly protein-methionine-S-oxide reductase) is an enzyme with systematic name peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (S)-S-oxide-forming).[1][2][3][4][5][6][7][8][9][10] This enzyme catalyses the following chemical reaction
- (1) peptide-L-methionine + thioredoxin disulfide + H2O [math]\displaystyle{ \rightleftharpoons }[/math] peptide-L-methionine (S)-S-oxide + thioredoxin
- (2) L-methionine + thioredoxin disulfide + H2O [math]\displaystyle{ \rightleftharpoons }[/math] L-methionine (S)-S-oxide + thioredoxin
The reaction occurs in the reverse direction.
References
- ↑ "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity". Biochemical and Biophysical Research Communications 290 (1): 62–5. January 2002. doi:10.1006/bbrc.2001.6171. PMID 11779133. https://zenodo.org/record/1229532.
- ↑ "Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine". Journal of Bacteriology 185 (14): 4119–26. July 2003. doi:10.1128/JB.185.14.4119-4126.2003. PMID 12837786.
- ↑ "Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress". Microbiology 149 (Pt 10): 2739–47. October 2003. doi:10.1099/mic.0.26442-0. PMID 14523107.
- ↑ "The enzymology and biochemistry of methionine sulfoxide reductases". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1703 (2): 231–8. January 2005. doi:10.1016/j.bbapap.2004.09.016. PMID 15680231.
- ↑ "Methionine sulfoxide reductases in prokaryotes". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1703 (2): 221–9. January 2005. doi:10.1016/j.bbapap.2004.08.017. PMID 15680230.
- ↑ "Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1703 (2): 203–12. January 2005. doi:10.1016/j.bbapap.2004.10.004. PMID 15680228.
- ↑ "The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1703 (2): 249–60. January 2005. doi:10.1016/j.bbapap.2004.09.008. PMID 15680233.
- ↑ "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells". The Biochemical Journal 373 (Pt 2): 531–7. July 2003. doi:10.1042/BJ20030443. PMID 12693988.
- ↑ "Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis". The Journal of Biological Chemistry 277 (14): 12016–22. April 2002. doi:10.1074/jbc.M112350200. PMID 11812798.
- ↑ "Enzymatic reduction of protein-bound methionine sulfoxide". Proceedings of the National Academy of Sciences of the United States of America 78 (4): 2155–8. April 1981. doi:10.1073/pnas.78.4.2155. PMID 7017726.
External links
- Peptide-methionine+(S)-S-oxide+reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
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