Biology:PRKAG1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

5'-AMP-activated protein kinase subunit gamma-1 is an enzyme that in humans is encoded by the PRKAG1 gene.[1][2][3]

Function

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[3]

Interactions

PRKAG1 has been shown to interact with PRKAB2[4] and PRKAB1.[4]

References

  1. "Mammalian AMP-activated protein kinase subfamily". The Journal of Biological Chemistry 271 (2): 611–4. January 1996. doi:10.1074/jbc.271.2.611. PMID 8557660. 
  2. "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". The Journal of Biological Chemistry 271 (15): 8675–81. April 1996. doi:10.1074/jbc.271.15.8675. PMID 8621499. 
  3. 3.0 3.1 "Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5571. 
  4. 4.0 4.1 "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". The Biochemical Journal 346 Pt 3 (3): 659–69. March 2000. doi:10.1042/0264-6021:3460659. PMID 10698692. 

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1)