Biology:PPP2CA
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Short description: Enzyme
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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that (in humans) is encoded by the PPP2CA gene.[1]
Function
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.[2]
Interactions
PPP2CA has been shown to interact with:
- Bcl-2,[3]
- Bestrophin 1,[4]
- CCNG2,[5]
- CTTNBP2NL,[6]
- CTTNBP2,[6]
- Cyclin-dependent kinase 2,[7]
- Cyclin-dependent kinase 6,[7]
- FAM40A,[6]
- IGBP1,[6][8][9][10]
- MOBKL3,[6]
- PPP2R1A,[6][11]
- PPP2R1B,[6][11]
- PPP2R2A,[6][12]
- PPP2R3B,[6][13]
- PPP2R5A,[6][14]
- PPP2R5B,[6][14]
- PPP2R5C,[6][14][15]
- PPP2R5D,[6][14]
- PPP2R5E,[6][14]
- STRN3,[6]
- STRN,[6] and
- TLX1.[16]
See also
- PPP2CB
References
- ↑ "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics 63 (1): 35–41. April 1993. doi:10.1159/000133497. PMID 8383590.
- ↑ "Entrez Gene: PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5515.
- ↑ "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A". The Journal of Biological Chemistry 273 (51): 34157–63. Dec 1998. doi:10.1074/jbc.273.51.34157. PMID 9852076.
- ↑ "Bestrophin interacts physically and functionally with protein phosphatase 2A". The Journal of Biological Chemistry 277 (34): 30591–7. Aug 2002. doi:10.1074/jbc.M204269200. PMID 12058047.
- ↑ "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". The Journal of Biological Chemistry 277 (30): 27449–67. Jul 2002. doi:10.1074/jbc.M111693200. PMID 11956189.
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. Jan 2009. doi:10.1074/mcp.M800266-MCP200. PMID 18782753.
- ↑ 7.0 7.1 "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms". The Journal of Biological Chemistry 275 (44): 34744–9. Nov 2000. doi:10.1074/jbc.M006210200. PMID 10934208.
- ↑ "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. Nov 2005. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
- ↑ "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. Jun 1998. doi:10.1006/bbrc.1998.8792. PMID 9647778.
- ↑ "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry 38 (32): 10371–6. Aug 1999. doi:10.1021/bi990902g. PMID 10441131.
- ↑ 11.0 11.1 "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal 369 (Pt 2): 387–98. Jan 2003. doi:10.1042/BJ20021244. PMID 12370081.
- ↑ "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". The Journal of Biological Chemistry 267 (30): 21864–72. Oct 1992. doi:10.1016/S0021-9258(19)36692-X. PMID 1328247.
- ↑ "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology 20 (3): 1021–9. Feb 2000. doi:10.1128/mcb.20.3.1021-1029.2000. PMID 10629059.
- ↑ 14.0 14.1 14.2 14.3 14.4 "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. Sep 1996. doi:10.1074/jbc.271.36.22081. PMID 8703017.
- ↑ "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal 19 (4): 562–71. Feb 2000. doi:10.1093/emboj/19.4.562. PMID 10675325.
- ↑ "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–8. Jan 1997. doi:10.1038/385454a0. PMID 9009195. Bibcode: 1997Natur.385..454K.
Further reading
- "Protein phosphatases come of age". The Journal of Biological Chemistry 264 (36): 21435–8. Dec 1989. doi:10.1016/S0021-9258(20)88197-6. PMID 2557326.
- "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical Pharmacology 60 (8): 1225–35. Oct 2000. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
- "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". The Journal of Biological Chemistry 267 (30): 21864–72. Oct 1992. doi:10.1016/S0021-9258(19)36692-X. PMID 1328247.
- "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]". FEBS Letters 312 (1): 95–9. Nov 1992. doi:10.1016/0014-5793(92)81418-L. PMID 1330687.
- "Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes". Biochemistry 30 (1): 89–97. Jan 1991. doi:10.1021/bi00215a014. PMID 1846293.
- "Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity". Journal of Virology 65 (4): 2098–101. Apr 1991. doi:10.1128/JVI.65.4.2098-2101.1991. PMID 1848320.
- "Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen". Molecular and Cellular Biology 11 (4): 1996–2003. Apr 1991. doi:10.1128/mcb.11.4.1996. PMID 1848668.
- "Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A". The EMBO Journal 8 (12): 3891–8. Dec 1989. doi:10.1002/j.1460-2075.1989.tb08568.x. PMID 2555176.
- "Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes". Proceedings of the National Academy of Sciences of the United States of America 85 (12): 4252–6. Jun 1988. doi:10.1073/pnas.85.12.4252. PMID 2837763. Bibcode: 1988PNAS...85.4252A.
- "The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit". Nucleic Acids Research 16 (23): 11365. Dec 1988. doi:10.1093/nar/16.23.11365. PMID 2849764.
- "Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis". The EMBO Journal 4 (13B): 3735–42. Dec 1985. doi:10.1002/j.1460-2075.1985.tb04142.x. PMID 4092695.
- "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry 270 (44): 26123–8. Nov 1995. doi:10.1074/jbc.270.44.26123. PMID 7592815.
- "The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo". The Journal of Biological Chemistry 269 (23): 16311–7. Jun 1994. doi:10.1016/S0021-9258(17)34009-7. PMID 8206937.
- "Regulation of elongation factor-2 by multisite phosphorylation". European Journal of Biochemistry 213 (2): 689–99. Apr 1993. doi:10.1111/j.1432-1033.1993.tb17809.x. PMID 8386634.
- "Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha)". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1178 (1): 117–20. Jul 1993. doi:10.1016/0167-4889(93)90117-8. PMID 8392375. https://zenodo.org/record/1258387.
- "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature 378 (6557): 641–4. Dec 1995. doi:10.1038/378641a0. PMID 8524402. Bibcode: 1995Natur.378..641K.
- "Structural and enzymatic aspects of rhodopsin phosphorylation". The Journal of Biological Chemistry 271 (9): 5215–24. Mar 1996. doi:10.1074/jbc.271.9.5215. PMID 8617805.
- "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. Sep 1996. doi:10.1074/jbc.271.36.22081. PMID 8703017.
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