Biology:PAFAH2
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Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene.[1][2][3] It is one of several PAF acetylhydrolases.
Function
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.[3]
References
- ↑ "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase". The Journal of Biological Chemistry 271 (51): 33032–8. Dec 1996. doi:10.1074/jbc.271.51.33032. PMID 8955149.
- ↑ "Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor". The Biochemical Journal 330 ( Pt 3) (3): 1309–15. Mar 1998. doi:10.1042/bj3301309. PMID 9494101.
- ↑ 3.0 3.1 "Entrez Gene: PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5051.
Further reading
- "Platelet-activating factor acetylhydrolases". The Journal of Biological Chemistry 272 (29): 17895–8. Jul 1997. doi:10.1074/jbc.272.29.17895. PMID 9218411.
- "Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia". Stroke: A Journal of Cerebral Circulation 38 (3): 1063–8. Mar 2007. doi:10.1161/01.STR.0000257981.09329.d2. PMID 17272759.
- "Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids". Atherosclerosis 196 (1): 420–4. Jan 2008. doi:10.1016/j.atherosclerosis.2006.11.027. PMID 17157859.
- "A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease". The Journal of Surgical Research 134 (1): 36–43. Jul 2006. doi:10.1016/j.jss.2006.02.058. PMID 16650870.
- "Identification of platelet-activating factor acetylhydrolase II in human skin". The Journal of Investigative Dermatology 119 (4): 913–9. Oct 2002. doi:10.1046/j.1523-1747.2002.01859.x. PMID 12406338.
- "Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme". Biochemistry 40 (15): 4539–49. Apr 2001. doi:10.1021/bi002600g. PMID 11294621. http://faculty.washington.edu/gelb/2001/bi002600g.pdf.
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