Biology:Nidogen
Nidogens, formerly known as entactins, are a family of sulfated monomeric glycoproteins located in the basal lamina[1] of parahoxozoans.[2] Two nidogens have been identified in humans: nidogen-1 (NID1) and nidogen-2 (NID2).[3] Remarkably, vertebrates are still capable of stabilizing basement membrane in the absence of either identified nidogen.[4] In contrast, those lacking both nidogen-1 and nidogen-2 typically die prematurely during embryonic development as a result of defects existing in the heart and lungs.[5] Nidogen have been shown to play a crucial role during organogenesis in late embryonic development, particularly in cardiac and lung development.[6] From an evolutionary perspective, nidogens are highly conserved across vertebrates and invertebrates, retaining their ability to bind laminin.[7] In nematodes, nidogen-1 is necessary for axon guidance, but not for basement membrane assembly.[8]
References
- ↑ Hortsch, Michael; Umemori, Hisashi (2009). The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. New York, NY: Springer. p. 66. ISBN 9780387927084. https://books.google.com/books?id=SACWPJTtXkoC&pg=PA66.
- ↑ Nielsen, C. (2019). Early animal evolution: A morphologist's view. Royal Society Open Science, 6 (7), 190638. https://doi.org/10.1098/rsos.190638
- ↑ "Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development". The Histochemical Journal 33 (9–10): 523–30. 2001. doi:10.1023/A:1014995523521. PMID 12005023.
- ↑ Kobe, Bostjan, ed (2014-11-11). "Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes". PLOS ONE 9 (11): e112886. doi:10.1371/journal.pone.0112886. PMID 25387007. Bibcode: 2014PLoSO...9k2886L.
- ↑ "A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction". Neural Development 3 (1): 24. September 2008. doi:10.1186/1749-8104-3-24. PMID 18817539.
- ↑ "Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice". Molecular and Cellular Biology 25 (15): 6846–56. August 2005. doi:10.1128/MCB.25.15.6846-6856.2005. PMID 16024816.
- ↑ "Structural and genetic analysis of laminin-nidogen interaction". Annals of the New York Academy of Sciences 857 (1): 130–42. October 1998. doi:10.1111/j.1749-6632.1998.tb10113.x. PMID 9917838. Bibcode: 1998NYASA.857..130M.
- ↑ Kim, S. (2000-04-07). "Positioning of Longitudinal Nerves in C. elegans by Nidogen". Science 288 (5463): 150–154. doi:10.1126/science.288.5463.150. ISSN 0036-8075. PMID 10753123. Bibcode: 2000Sci...288..150K.
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