Biology:NRD1
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Nardilysin is a protein that in humans is encoded by the NRD1 gene.[1][2][3]
Interactions
NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.[4]
References
- ↑ "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J 327 (3): 773–9. May 1998. doi:10.1042/bj3270773. PMID 9581555.
- ↑ "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics 47 (2): 238–45. Apr 1998. doi:10.1006/geno.1997.5078. PMID 9479496.
- ↑ "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4898.
- ↑ Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. (England) 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMID 11432822.
Further reading
- "Precursor convertases in the secretory pathway, cytosol and extracellular milieu.". Essays Biochem. 38: 79–94. 2003. doi:10.1042/bse0380079. PMID 12463163.
- "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation.". Protein Pept. Lett. 11 (5): 501–8. 2005. doi:10.2174/0929866043406508. PMID 15544571.
- "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines.". Biochem. J. 351 (3): 755–64. 2001. doi:10.1042/0264-6021:3510755. PMID 11042131.
- "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.". EMBO J. 20 (13): 3342–50. 2001. doi:10.1093/emboj/20.13.3342. PMID 11432822.
- "Expression of the acidic stretch of nardilysin as a functional binding domain.". Biochemistry 40 (31): 9447–52. 2001. doi:10.1021/bi010538x. PMID 11478915.
- "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).". Biochem. J. 367 (Pt 1): 229–38. 2003. doi:10.1042/BJ20020822. PMID 12095415.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Nardilysin cleaves peptides at monobasic sites.". Biochemistry 42 (7): 2239–44. 2003. doi:10.1021/bi027178d. PMID 12590613.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.". J. Biol. Chem. 281 (41): 31164–72. 2006. doi:10.1074/jbc.M601316200. PMID 16923819.
- "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons.". Neuroscience 146 (4): 1513–23. 2007. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499.
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