Biology:NDEL1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.[1][2][3]
This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]
Interactions
NDEL1 has been shown to interact with Cyclin-dependent kinase 5,[1] YWHAE,[4] PAFAH1B1[1][4] and DISC1.[5][6]
References
- ↑ 1.0 1.1 1.2 "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron 28 (3): 697–711. Dec 2000. doi:10.1016/S0896-6273(00)00147-1. PMID 11163260.
- ↑ "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron 28 (3): 681–96. Dec 2000. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259.
- ↑ 3.0 3.1 "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81565.
- ↑ 4.0 4.1 "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics 34 (3): 274–85. Jul 2003. doi:10.1038/ng1169. PMID 12796778.
- ↑ "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics 12 (13): 1591–608. Jul 2003. doi:10.1093/hmg/ddg162. PMID 12812986.
- ↑ "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America 100 (1): 289–94. Jan 2003. doi:10.1073/pnas.0136913100. PMID 12506198. Bibcode: 2003PNAS..100..289O.
Further reading
- "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. Apr 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. Apr 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. Mar 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron 28 (3): 665–79. Dec 2000. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
- "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America 100 (1): 289–94. Jan 2003. doi:10.1073/pnas.0136913100. PMID 12506198. Bibcode: 2003PNAS..100..289O.
- "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle". Molecular and Cellular Biology 23 (4): 1239–50. Feb 2003. doi:10.1128/MCB.23.4.1239-1250.2003. PMID 12556484.
- "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". American Journal of Human Genetics 72 (4): 918–30. Apr 2003. doi:10.1086/374320. PMID 12621583.
- "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics 34 (3): 274–85. Jul 2003. doi:10.1038/ng1169. PMID 12796778.
- "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics 12 (13): 1591–608. Jul 2003. doi:10.1093/hmg/ddg162. PMID 12812986.
- "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders". Molecular and Cellular Neurosciences 25 (1): 42–55. Jan 2004. doi:10.1016/j.mcn.2003.09.009. PMID 14962739.
- "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein". The Journal of Cell Biology 164 (4): 557–66. Feb 2004. doi:10.1083/jcb.200308058. PMID 14970193.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase". Neuron 44 (5): 809–21. Dec 2004. doi:10.1016/j.neuron.2004.11.019. PMID 15572112.
- "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1". Proceedings of the National Academy of Sciences of the United States of America 102 (10): 3828–33. Mar 2005. doi:10.1073/pnas.0500330102. PMID 15728732. Bibcode: 2005PNAS..102.3828H.
- "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1730 (1): 77–84. Jul 2005. doi:10.1016/j.bbaexp.2005.06.001. PMID 16005531.
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