Biology:N2-citryl-N6-acetyl-N6-hydroxylysine synthase

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Short description: Class of enzymes


N2-citryl-N6-acetyl-N6-hydroxylysine synthase
Identifiers
EC number6.3.2.38
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

N2-citryl-N6-acetyl-N6-hydroxylysine synthase (EC 6.3.2.38, N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase, iucA (gene)) is an enzyme with systematic name citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine

This enzyme requires Mg2+.

References

  1. "Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1". Biochim. Biophys. Acta 801 (3): 437–443. 1984. doi:10.1016/0304-4165(84)90150-8. 
  2. "The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I". Biochimica et Biophysica Acta (BBA) - General Subjects 192 (2): 175–84. November 1969. doi:10.1016/0304-4165(69)90353-5. PMID 4313071. 
  3. "Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N6-acetyl-N6-hydroxylysine". J. Am. Chem. Soc. 104 (11): 3096–3101. 1982. doi:10.1021/ja00375a025. 
  4. "Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12". Journal of Bacteriology 165 (2): 570–8. February 1986. doi:10.1128/jb.165.2.570-578.1986. PMID 2935523. 
  5. "A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases". ChemBioChem 6 (4): 601–11. April 2005. doi:10.1002/cbic.200400283. PMID 15719346. 

External links