Biology:N,N'-diacetyllegionaminate synthase
From HandWiki
| N,N'-diacetyllegionaminate synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.5.1.101 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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N,N'-diacetyllegionaminate synthase (EC 2.5.1.101, neuB (gene), legI (gene)) is an enzyme with systematic name phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase.[1][2] This enzyme catalyses the following chemical reaction
- 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] N,N'-diacetyllegionaminate + phosphate
This enzyme requires a divalent metal such as Mn2+.
References
- ↑ "Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila". Biochemistry 47 (10): 3272–82. March 2008. doi:10.1021/bi702364s. PMID 18275154.
- ↑ "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology 19 (7): 715–25. July 2009. doi:10.1093/glycob/cwp039. PMID 19282391.
External links
- N,N'-diacetyllegionaminate+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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