Biology:Myo-inosose-2 dehydratase

From HandWiki
myo-inosose-2 dehydratase
Identifiers
EC number4.2.1.44
CAS number37290-79-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme myo-inosose-2 dehydratase (EC 4.2.1.44) catalyzes the chemical reaction

2,4,6/3,5-pentahydroxycyclohexanone [math]\displaystyle{ \rightleftharpoons }[/math] 3,5/4-trihydroxycyclohexa-1,2-dione + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming). Other names in common use include inosose 2,3-dehydratase, ketoinositol dehydratase, and 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase. This enzyme participates in inositol phosphate metabolism. It has 2 cofactors: manganese, and Cobalt.

References

  • "The pathway of myo-inositol degradation in Aerobacter aerogenes Dehydrogenation and dehydration". J. Biol. Chem. 241 (4): 800–6. 1966. PMID 5905122.