Biology:Linoleate 11-lipoxygenase

From HandWiki
linoleate 11-lipoxygenase
Identifiers
EC number1.13.11.45
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a linoleate 11-lipoxygenase (EC 1.13.11.45) is an enzyme that catalyzes the chemical reaction

linoleate + O2 [math]\displaystyle{ \rightleftharpoons }[/math] (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate

Thus, the two substrates of this enzyme are linoleate and O2, whereas its product is (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is linoleate:oxygen 11S-oxidoreductase. This enzyme is also called linoleate dioxygenase, manganese lipoxygenase. This enzyme participates in linoleic acid metabolism.

References

  • "Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction". J. Biol. Chem. 273 (21): 13080–8. 1998. doi:10.1074/jbc.273.21.13080. PMID 9582346. 
  • "Analysis of novel hydroperoxides and other metabolites of oleic, linoleic, and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn". Lipids 33 (9): 843–52. 1998. doi:10.1007/s11745-998-0280-0. PMID 9778131. 
  • "Manganese lipoxygenase. Purification and characterization". J. Biol. Chem. 273 (21): 13072–9. 1998. doi:10.1074/jbc.273.21.13072. PMID 9582345.