Biology:Leishmania mexicana
| Leishmania mexicana | |
|---|---|
| |
| Leishmania mexicana in a biopsy specimen from a skin lesion stained with H&E. The amastigotes are lining the walls of two vacuoles, a typical arrangement. The species identification was derived from culture followed by isoenzyme analysis. | |
Scientific classification 
| |
| Domain: | Eukaryota |
| Phylum: | Euglenozoa |
| Class: | Kinetoplastea |
| Order: | Trypanosomatida |
| Genus: | Leishmania |
| Species: | L. mexicana
|
| Binomial name | |
| Leishmania mexicana Biagi, 1953, emend. Garnham, 1962
| |
Leishmania mexicana is a species of obligate intracellular parasites of the protozoan genus Leishmania. In Mexico and Central America, this parasite is the primary cause of cutaneous leishmaniasis.[1]
Infected sandflies carry L. mexicana in its promastigote form, transmitting it from their salivary glands through their proboscis into the bloodstream of the host. When macrophages phagocytize the parasite, it transitions into its amastigote form, rapidly dividing to break the host cell open and infect other mononuclear phagocytic cells. When uninfected sandflies ingest the blood of an infected animal, they acquire L. mexicana, which returns to the promastigote form to efficiently survive in the insect's midgut.[2]
Leishmania mexicana can induce the cutaneous and diffuse cutaneous clinical manifestations in humans and certain other mammalian hosts. The cutaneous type develops an ulcer at the bite site, here the amastigotes do not spread and the ulcers become visible either a few days or several months after the initial bite. The diffuse cutaneous type begins when the amastigote diffuses through the skin and metastasize to other tissue. This type does not produce ulcers and there is no treatment.
Treatment of Leishmaniasis caused by L. mexicana consists of pentavalent antimonials as Pentostam or Glucantime injected direct into the ulcer or Intramuscular.
Prevention of L. mexicana infection is principally avoiding the bite of the infected sandfly.
References
- ↑ "Synthesis of proteophosphoglycans of Leishmania major and Leishmania mexicana". J. Org. Chem. 70 (5): 1691–7. March 2005. doi:10.1021/jo048443z. PMID 15730289.
- ↑ "Leishmaniasis". 14 December 2017. https://www.cdc.gov/dpdx/leishmaniasis/index.html.
- "Leishmania mexicana infection of the eyelid in a traveler to Belize". Braz J Infect Dis 11 (1): 149–52. February 2007. doi:10.1590/s1413-86702007000100030. PMID 17625744.
- "Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array". Microbiology 140 (Pt 2): 417–24. February 1994. doi:10.1099/13500872-140-2-417. PMID 8180705.
- "Structure of Leishmania mexicana lipophosphoglycan". J. Biol. Chem. 267 (10): 6834–40. April 1992. doi:10.1016/S0021-9258(19)50502-6. PMID 1551890. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=1551890.
- "Leishmania mexicana Strains Isolated from Both Localized Cutaneous (LCL) and Diffuse Cutaneous (DCL) Lesions in Humans Can Produce DCL in Mice, Being Faster in Males". American Society for Microbiology. 2003. ISBN 978-1-55581-284-3.
- "Clinical spectrum of Leishmaniasis". Clin Infect Dis 22: 1–13. 1996. doi:10.1093/clinids/22.1.1. PMID 8824958.
- "The immunology of susceptibility and resistance to Leishmania major in mice". Nat Rev Immunol 2 (11): 845–58. 2002. doi:10.1038/nri933. PMID 12415308.
Wikidata ☰ Q2493771 entry
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