Biology:KDM4D
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.[1][2] KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.
In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material.[3][4] A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.[5]
References
- ↑ "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology 24 (6): 1623–8. June 2004. doi:10.3892/ijo.25.3.759. PMID 15138608.
- ↑ "Entrez Gene: JMJD2D jumonji domain containing 2D". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55693.
- ↑ "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell 172 (4): 881–887.e7. February 2018. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
- ↑ Stein, Rob (24 January 2018). "Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep". National Public Radio. https://www.npr.org/sections/health-shots/2018/01/24/579925801/chinese-scientists-clone-monkeys-using-method-that-created-dolly-the-sheep. Retrieved 24 January 2018.
- ↑ "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming". Development 145 (4): dev158261. February 2018. doi:10.1242/dev.158261. PMID 29453221.
Further reading
- "Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D". Biochemical and Biophysical Research Communications 359 (3): 742–6. August 2007. doi:10.1016/j.bbrc.2007.05.179. PMID 17555712.
- "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell 125 (3): 467–81. May 2006. doi:10.1016/j.cell.2006.03.028. PMID 16603238.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
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