Biology:IHPK1
From HandWiki
 Generic protein structure example |
Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene.[1]
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described.[1]
References
Further reading
- "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. 1997. doi:10.1093/dnares/3.5.321. PMID 9039502.
- "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3.". Somat. Cell Mol. Genet. 24 (1): 71–4. 1998. doi:10.1007/BF02677496. PMID 9776982.
- "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase.". FEBS Lett. 461 (3): 169–72. 1999. doi:10.1016/S0014-5793(99)01462-3. PMID 10567691.
- "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.". Curr. Biol. 9 (22): 1323–6. 2000. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
- "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis.". J. Biol. Chem. 275 (32): 24686–92. 2000. doi:10.1074/jbc.M002750200. PMID 10827188.
- "Identification and characterization of a novel inositol hexakisphosphate kinase.". J. Biol. Chem. 276 (42): 39179–85. 2001. doi:10.1074/jbc.M106842200. PMID 11502751.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus.". J. Hum. Genet. 49 (7): 360–5. 2004. doi:10.1007/s10038-004-0158-z. PMID 15221640.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514.
See also
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