Biology:IFNK
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Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.[1][2][3]
Function
IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: interferon". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56832.
- ↑ "Interferon-kappa, a novel type I interferon expressed in human keratinocytes". J. Biol. Chem. 276 (43): 39765–71. October 2001. doi:10.1074/jbc.M102502200. PMID 11514542.
- ↑ "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system". J. Immunol. 169 (9): 4822–30. November 2002. doi:10.4049/jimmunol.169.9.4822. PMID 12391192.
3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]
Further reading
- "Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis". Mol. Med. 14 (9–10): 575–81. 2008. doi:10.2119/2008-00056.Liu. PMID 18615156.
- "IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes.". Lab. Invest. 90 (10): 1482–91. 2010. doi:10.1038/labinvest.2010.95. PMID 20479716.
- "Dengue hemorrhagic fever is associated with polymorphisms in JAK1.". Eur. J. Hum. Genet. 18 (11): 1221–7. 2010. doi:10.1038/ejhg.2010.98. PMID 20588308.
- "Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.". Fam. Cancer 9 (4): 625–33. 2010. doi:10.1007/s10689-010-9356-3. PMID 20574843.
- "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.". Nat. Genet. 42 (9): 777–80. 2010. doi:10.1038/ng.644. PMID 20694011.
- "Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.". Lancet Neurol 9 (10): 978–85. 2010. doi:10.1016/S1474-4422(10)70184-8. PMID 20801718.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells.". Cancer Res. 69 (22): 8718–25. 2009. doi:10.1158/0008-5472.CAN-09-0550. PMID 19887612.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. 2004. doi:10.1110/ps.04682504. PMID 15340161.
- "Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.". Nat. Genet. 41 (10): 1083–7. 2009. doi:10.1038/ng.442. PMID 19734901.
- "The role of genetic variation near interferon-kappa in systemic lupus erythematosus". J. Biomed. Biotechnol. 2010: 1–11. 2010. doi:10.1155/2010/706825. PMID 20706608.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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