Biology:Human endogenous retrovirus K endopeptidase

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Human endogenous retrovirus K endopeptidase
Identifiers
EC number3.4.23.50
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Human endogenous retrovirus K endopeptidase (EC 3.4.23.50, human endogenous retrovirus K10 endopeptidase, endogenous retrovirus HERV-K10 putative protease, human endogenous retrovirus K retropepsin, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K113 protease, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin) is an enzyme derived from an endogenous retrovirus.[1] This enzyme catalyses the following chemical reaction:

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-PIVQ- cleavage site.

This enzyme belongs to the peptidase family A2 (retropepsins).

References

  1. "Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease?". Biochemistry 37 (49): 17137–44. December 1998. doi:10.1021/bi9818927. PMID 9860826. 

External links