Biology:HDAC10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.[1][2][3]
Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM][3]
Interactions
HDAC10 has been shown to interact with Histone deacetylase 2[4] and Nuclear receptor co-repressor 2.[4]
See also
References
- ↑ "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem 277 (1): 187–93. Jan 2002. doi:10.1074/jbc.M108931200. PMID 11677242.
- ↑ "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem 277 (5): 3350–6. Jan 2002. doi:10.1074/jbc.M109861200. PMID 11726666.
- ↑ 3.0 3.1 "Entrez Gene: HDAC10 histone deacetylase 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83933.
- ↑ 4.0 4.1 Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland et al. (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. (United States) 277 (8): 6656–66. doi:10.1074/jbc.M108055200. ISSN 0021-9258. PMID 11739383.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- Dunham I; Shimizu N; Roe BA et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- Fischer DD; Cai R; Bhatia U et al. (2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. 277 (8): 6656–66. doi:10.1074/jbc.M108055200. PMID 11739383.
- "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain". Nucleic Acids Res. 30 (5): 1114–23. 2002. doi:10.1093/nar/30.5.1114. PMID 11861901.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. 2004. doi:10.1074/jbc.C300407200. PMID 14578343.
- "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- Osada H; Tatematsu Y; Saito H et al. (2004). "Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients". Int. J. Cancer 112 (1): 26–32. doi:10.1002/ijc.20395. PMID 15305372.
- Collins JE; Wright CL; Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
External links
- HDAC10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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