Biology:Guanidinopropionase

From HandWiki
guanidinopropionase
Identifiers
EC number3.5.3.17
CAS number68821-77-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a guanidinopropionase (EC 3.5.3.17) is an enzyme that catalyzes the chemical reaction

3-guanidinopropanoate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] beta-alanine + urea

Thus, the two substrates of this enzyme are 3-guanidinopropanoate and H2O, whereas its two products are beta-alanine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is 3-guanidinopropanoate amidinopropionase. Other names in common use include GPase and GPH. It employs one cofactor, manganese.

References

  • "Characterization of 3-guanidinopropionate amidinohydrolase from Pseudomonas aeruginosa and a comparative study with 4- guanidinobutyrate amidinohydrolase from another Pseudomonas". Agric. Biol. Chem. 46 (5): 1361–1363. 1982. doi:10.1271/bbb1961.46.1361.