Biology:Glutarate—CoA ligase

From HandWiki
Glutarate—CoA ligase
Identifiers
EC number6.2.1.6
CAS number9023-68-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glutarate—CoA ligase (EC 6.2.1.6) is an enzyme that catalyzes the chemical reaction

ATP + glutarate + CoA [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate + glutaryl-CoA

The 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is glutarate:CoA ligase (ADP-forming). Other names in common use include glutaryl-CoA synthetase, and glutaryl coenzyme A synthetase. This enzyme participates in fatty acid metabolism and lysine degradation.

References