Biology:GABRR1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.

See also

• GABA_A-ρ receptor

Further reading

• "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors". J. Neurosci. 15 (11): 7684–7691. 1995. doi:10.1523/jneurosci.15-11-07684.1995. PMID 7472519. 
• "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction". J. Biol. Chem. 272 (21): 13750–13757. 1997. doi:10.1074/jbc.272.21.13750. PMID 9153229. 
• "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation". Neurosci. Lett. 255 (1): 17–20. 1999. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716. 
• "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature 397 (6714): 66–69. 1999. doi:10.1038/16258. PMID 9892354. Bibcode: 1999Natur.397...66H. 
• "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta 1447 (2–3): 307–312. 1999. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332. 
• "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1". J. Biol. Chem. 275 (2): 840–846. 2000. doi:10.1074/jbc.275.2.840. PMID 10625616. 
• "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C". Mol. Pharmacol. 57 (5): 847–856. 2000. PMID 10779366. 
• "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–8650. 2001. doi:10.1523/jneurosci.20-23-08643.2000. PMID 11102469. 
• "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes". Biomed. Environ. Sci. 14 (4): 269–277. 2002. PMID 11862606. 
• "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–246. 2002. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859. 
• "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening". J. Biol. Chem. 277 (46): 43741–43748. 2003. doi:10.1074/jbc.M202007200. PMID 12226075. 
• "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. 2003. doi:10.1074/jbc.M205162200. PMID 12431995. 
• "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–811. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M. 
• "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels". J. Biol. Chem. 279 (8): 6967–6975. 2004. doi:10.1074/jbc.M307772200. PMID 14660627. 
• "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism". Arch. Med. Res. 35 (3): 194–198. 2004. doi:10.1016/j.arcmed.2003.12.002. PMID 15163459. 
• "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model". J. Biol. Chem. 280 (2): 1535–1542. 2005. doi:10.1074/jbc.M409908200. PMID 15548535. 
• "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina". Neuroscience 136 (2): 467–475. 2006. doi:10.1016/j.neuroscience.2005.08.018. PMID 16198491. 

External links

• GABRR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.