Biology:Exodeoxyribonuclease (lambda-induced)
From HandWiki
| Exodeoxyribonuclease (lambda-induced) | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.11.3 | ||||||||
| CAS number | 37367-70-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Exodeoxyribonuclease (lambda-induced) (EC 3.1.11.3, lambda exonuclease, phage lambda-induced exonuclease, Escherichia coli exonuclease IV, E. coli exonuclease IV, exodeoxyribonuclease IV, exonuclease IV) is an exonuclease.[1][2] This enzyme catalyses the following chemical reaction
- Exonucleolytic cleavage in the 5′- to 3′-direction to yield nucleoside 5′-phosphates
This enzyme has preference for double-stranded DNA (dsDNA). This means that it degrades a single strand of dsDNA, primarily any strand which has a phosphate at its 5' end.[3]
References
- ↑ "Deoxyribonuclease IV: a new exonuclease from mammalian tissues". Proceedings of the National Academy of Sciences of the United States of America 62 (2): 597–603. February 1969. doi:10.1073/pnas.62.2.597. PMID 5256235.
- ↑ "An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction". The Journal of Biological Chemistry 242 (4): 679–86. February 1967. doi:10.1016/S0021-9258(18)96258-7. PMID 6017737.
- ↑ "Lambda Exonuclease". Epicentre. http://www.epibio.com/docs/default-source/protocols/lambda-exonuclease.pdf.
External links
- Exodeoxyribonuclease+(lambda-induced) at the US National Library of Medicine Medical Subject Headings (MeSH)
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