Biology:DUSP1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.[1][2]
Function
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.[3]
Interactions
DUSP1 has been shown to interact with MAPK14,[4][5] MAPK1[5][6] and MAPK8.[5]
References
- ↑ "Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase". Nature 359 (6396): 644–7. Oct 1992. doi:10.1038/359644a0. PMID 1406996. Bibcode: 1992Natur.359..644K.
- ↑ "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases". Genomics 22 (2): 462–4. Jul 1994. doi:10.1006/geno.1994.1411. PMID 7806236. https://deepblue.lib.umich.edu/bitstream/2027.42/31442/1/0000360.pdf.
- ↑ "Entrez Gene: DUSP1 dual specificity phosphatase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1843.
- ↑ "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". The Journal of Biological Chemistry 276 (28): 26629–39. Jul 2001. doi:10.1074/jbc.M101981200. PMID 11359773.
- ↑ 5.0 5.1 5.2 "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The Journal of Biological Chemistry 276 (19): 16491–500. May 2001. doi:10.1074/jbc.M010966200. PMID 11278799.
- ↑ "Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma". Cancer Research 68 (11): 4192–200. Jun 2008. doi:10.1158/0008-5472.CAN-07-6157. PMID 18519678.
Further reading
- "The "VH1-like" dual-specificity protein tyrosine phosphatases". Molecules and Cells 8 (1): 2–11. Feb 1998. PMID 9571625.
- "Protein phosphatases and the regulation of MAP kinase activity". Seminars in Cell & Developmental Biology 9 (2): 143–52. Apr 1998. doi:10.1006/scdb.1997.0219. PMID 9599409.
- "Dual-specificity phosphatase 1: a critical regulator of innate immune responses". Biochemical Society Transactions 34 (Pt 6): 1018–23. Dec 2006. doi:10.1042/BST0341018. PMID 17073741.
- "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". The Journal of Biological Chemistry 270 (13): 7420–6. Mar 1995. doi:10.1074/jbc.270.13.7420. PMID 7535770.
- "Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene". The Journal of Biological Chemistry 269 (5): 3596–604. Feb 1994. doi:10.1016/S0021-9258(17)41905-3. PMID 8106404.
- "The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34". Human Genetics 93 (5): 513–6. May 1994. doi:10.1007/BF00202814. PMID 8168826.
- "MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo". Cell 75 (3): 487–93. Nov 1993. doi:10.1016/0092-8674(93)90383-2. PMID 8221888.
- "The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase". Proceedings of the National Academy of Sciences of the United States of America 90 (11): 5292–6. Jun 1993. doi:10.1073/pnas.90.11.5292. PMID 8389479. Bibcode: 1993PNAS...90.5292C.
- "The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts". Oncogene 8 (7): 2015–20. Jul 1993. PMID 8390041.
- "Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation". Science 286 (5449): 2514–7. Dec 1999. doi:10.1126/science.286.5449.2514. PMID 10617468.
- "Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation". The Biochemical Journal 352 (1): 155–63. Nov 2000. doi:10.1042/0264-6021:3520155. PMID 11062068.
- "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The Journal of Biological Chemistry 276 (19): 16491–500. May 2001. doi:10.1074/jbc.M010966200. PMID 11278799.
- "CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential". Oncogene 21 (28): 4435–47. Jun 2002. doi:10.1038/sj.onc.1205542. PMID 12080474.
- "Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2". The Journal of Biological Chemistry 277 (49): 47444–50. Dec 2002. doi:10.1074/jbc.M208140200. PMID 12356755.
- "Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38". Molecular and Cellular Biology 22 (22): 7802–11. Nov 2002. doi:10.1128/MCB.22.22.7802-7811.2002. PMID 12391149.
- "Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma". International Journal of Cancer 102 (5): 507–13. Dec 2002. doi:10.1002/ijc.10746. PMID 12432554.
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