Biology:DISC2
From HandWiki
Short description: Non-coding RNA in the species Homo sapiens
 Generic protein structure example |
In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is a long non-coding RNA molecule. In humans, the DISC2 gene that produces the DISC2 RNA molecule is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia.[1] It is antisense to the DISC1 gene and may regulate the expression of DISC1.[1][2] DISC2 may also contribute to other psychiatric disorders.[2][3]
See also
- Long noncoding RNA
References
- ↑ 1.0 1.1 "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics 9 (9): 1415–1423. May 2000. doi:10.1093/hmg/9.9.1415. PMID 10814723.
- ↑ 2.0 2.1 "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine 36 (5): 367–378. 2004. doi:10.1080/07853890410033603. PMID 15478311.
- ↑ "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder". American Journal of Human Genetics 75 (5): 862–872. Nov 2004. doi:10.1086/425586. PMID 15386212.
Further reading
- "Molecular genetics of bipolar disorder". Neuroscience Research 40 (2): 105–113. Jun 2001. doi:10.1016/s0168-0102(01)00221-8. PMID 11377748.
- "Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family". American Journal of Human Genetics 69 (2): 428–433. Aug 2001. doi:10.1086/321969. PMID 11443544.
- "Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder". Psychiatric Genetics 11 (2): 71–78. Jun 2001. doi:10.1097/00041444-200106000-00003. PMID 11525420.
- "Evolutionary constraints on the Disrupted in Schizophrenia locus". Genomics 81 (1): 67–77. Jan 2003. doi:10.1016/S0888-7543(02)00026-5. PMID 12573262.
- "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine 36 (5): 367–378. 2004. doi:10.1080/07853890410033603. PMID 15478311.
- "The genetics of bipolar affective disorder". Current Opinion in Psychiatry 20 (1): 8–12. Jan 2007. doi:10.1097/YCO.0b013e3280117722. PMID 17143075.
- "The DISC locus in psychiatric illness". Molecular Psychiatry 13 (1): 36–64. Jan 2008. doi:10.1038/sj.mp.4002106. PMID 17912248.
- "A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder". American Journal of Medical Genetics Part A 149A (8): 1758–1762. Aug 2009. doi:10.1002/ajmg.a.32941. PMID 19606485.
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